Research entry
Semax
Decades of neuroscience research behind it
In plain terms
Semax is based on a short fragment of ACTH, a hormone the body makes. Research, largely Russian, has investigated it for effects on BDNF levels, attention and memory tasks in animal models.
Research overview
Semax is a synthetic heptapeptide analog of ACTH (adrenocorticotropic hormone). Originally developed in Russia, laboratory research has investigated its neuroprotective properties and effects on brain-derived neurotrophic factor (BDNF) expression. Studies have examined its role in neurological research models including cognitive and neuroprotective applications.
What has been studied
- 1
Derived from ACTH
Semax is a short peptide based on a fragment of ACTH, modified so it lasts longer. It was developed in Russia, where most of the published research originates.
- 2
BDNF signalling
Rodent studies have measured brain-derived neurotrophic factor, a protein involved in the growth and survival of neurons.
- 3
Learning and memory models
Animal research has used maze and avoidance tasks to look at learning and memory endpoints.
- 4
Neuroprotection models
Rodent work has examined tissue outcomes after restricted blood flow to the brain.
Research articles
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