Pinealon

In plain terms

Pinealon is a synthetic tripeptide developed in Russian research institutes. Laboratory work has investigated it for effects on neuronal cell survival under stress and on markers of cognitive performance in animal studies.

Research overview

Pinealon is a three-amino-acid peptide (Glu-Asp-Arg) from the Khavinson programme of research into very short peptides derived from tissue extracts. Cell studies have looked at whether it protects neurons under oxidative or low-oxygen stress. The programme proposes that peptides this short act by binding DNA directly and changing gene activity — a mechanism that is still debated in the literature.

What has been studied

1. 1

   A short pineal-derived peptide

   Pinealon is a three-amino-acid peptide from the Khavinson body of research, which studied very short peptides derived from tissue extracts.

2. 2

   Neuronal protection models

   Cell studies have looked at whether it protects neurons under oxidative or low-oxygen stress.

3. 3

   Gene activity

   The research programme it comes from proposes that short peptides act by binding DNA directly and changing which genes are active — a mechanism still debated.

Research articles

• [Investigation of antihypoxic properties of short peptides]Advances in gerontology = Uspekhi gerontologii · 2008
• [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION]Advances in gerontology = Uspekhi gerontologii · 2015
• [Neuroprotective effects of peptides bioregulators in people of various age]Advances in gerontology = Uspekhi gerontologii · 2013
• EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's DiseaseMolecules (Basel, Switzerland) · 2020