Research entry

Kisspeptin

Sits at the top of the reproductive hormone chain

In plain terms

Kisspeptin is a peptide that acts on the KISS1 receptor in the brain. Research has focused on its role as an upstream signal in the chain that controls reproductive hormones — it prompts the release of GnRH, which sets the rest of the sequence in motion. Studies are in animals and in laboratory models.

Research overview

Kisspeptin acts on the KISS1 receptor in the hypothalamus and triggers GnRH release, which starts the chain controlling reproductive hormones. Its role was identified through work on families with delayed puberty in whom the receptor was non-functional. Animal studies have mapped where kisspeptin neurons sit and what they respond to.

What has been studied

1
Upstream of the reproductive axis
Kisspeptin acts on the KISS1 receptor in the hypothalamus and triggers GnRH release, which starts the chain controlling reproductive hormones.
2
Puberty research
Its role was identified through work on families with delayed puberty, where the receptor was found to be non-functional.
3
Neuroendocrine signalling
Animal studies have mapped where the kisspeptin-producing neurons sit and what they respond to.

Research articles

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