Research entry
IGF-1 LR3
Modified to last longer in the dish
In plain terms
IGF-1 LR3 is a modified form of insulin-like growth factor 1 that breaks down more slowly in laboratory conditions. Research has examined it for effects on cell growth, protein synthesis and muscle cell differentiation in culture.
Research overview
IGF-1 LR3 is an 83-amino acid synthetic analogue of human IGF-1, engineered to evade insulin-like growth factor binding proteins. Preclinical laboratory studies heavily utilize it to investigate cellular hyperplasia, skeletal muscle regeneration, and localized tissue repair over prolonged periods due to its extended half-life.
What has been studied
- 1
A longer-acting IGF-1
IGF-1 LR3 is a modified insulin-like growth factor 1. The modifications reduce how strongly it binds to the carrier proteins that normally hold IGF-1 inactive.
- 2
The mediator of growth hormone
Most of what growth hormone is measured to do is attributed to IGF-1, which is why it is the standard readout in that research.
- 3
Cell growth and protein synthesis
Cell-culture work has studied its effect on cell division and on the rate at which cells build protein.
Research articles
- Immunoelectron microscopic localization of one of the spore germination proteins, GerAB, in Bacillus subtilis sporesJournal of bacteriology · 1995
- Recombinant neuraminidase vaccine protects against lethal influenzaVaccine · 1996
- Correction of optic disc measurements on fundus photographsGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1992
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