Research entry
CJC-1295 / Ipamorelin (No DAC)
Two compounds that act on different receptors
In plain terms
This blend pairs CJC-1295 (without DAC) with ipamorelin. They reach the growth-hormone axis by two separate routes — CJC-1295 at the GHRH receptor, ipamorelin at the ghrelin receptor — which is why they are studied together rather than separately. The published work is in animal and cell models.
Research overview
CJC-1295 is a long-acting synthetic analog of growth hormone-releasing hormone (GHRH). Ipamorelin is a selective growth hormone secretagogue. Laboratory research has investigated the combination for its synergistic effects on pulsatile growth hormone release and IGF-1 signaling. Studies have examined their potential roles in tissue repair and metabolic research models.
What has been studied
- 1
Two receptors, two routes
CJC-1295 acts at the GHRH receptor and ipamorelin at the ghrelin receptor. They are studied together because they reach the same axis by separate paths.
- 2
Selectivity
Ipamorelin is studied partly for what it does not do — research has looked at its selectivity compared with earlier ghrelin-receptor compounds that also moved cortisol and prolactin.
- 3
Pulse patterns
Animal work has measured the shape and timing of growth-hormone release rather than only its total amount.
Research articles
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future DirectionsJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
- Ipamorelin, the first selective growth hormone secretagogueEuropean journal of endocrinology · 1998
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsThe Journal of clinical endocrinology and metabolism · 2006
- Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjectsGrowth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2009
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