Research entry

SS-31

Designed to reach the mitochondria

In plain terms

SS-31 is a four-amino-acid peptide that concentrates at the inner mitochondrial membrane, binding a fat called cardiolipin. Research has examined it for effects on mitochondrial energy output and oxidative stress in cell and animal models.

Research overview

SS-31 (elamipretide) is a four-amino-acid peptide that binds cardiolipin, a lipid found almost only in the inner mitochondrial membrane. That selectivity is why it is studied where it is: cell and animal work on how efficiently mitochondria produce ATP, and on tissue damage from reactive oxygen species in kidney, heart and muscle models. It has progressed further into human trials than most compounds in this catalogue.

What has been studied

1
Targets the mitochondrial membrane
SS-31 binds to cardiolipin, a lipid found almost exclusively in the inner mitochondrial membrane. That selectivity is the reason it is studied where it is.
2
Energy production efficiency
Cell studies have measured whether it changes how efficiently mitochondria produce ATP.
3
Oxidative stress models
Animal research has looked at tissue damage from reactive oxygen species, in kidney, heart and muscle models.

Research articles

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