Research entry

Cagrilintide

A long-acting version of a pancreatic hormone

In plain terms

Cagrilintide is a longer-lasting analogue of amylin, released by the pancreas alongside insulin. Trials have investigated this class for effects on appetite signalling, gastric emptying and body weight.

Research overview

Cagrilintide is a long-acting analogue of amylin, a hormone released alongside insulin. It acts on amylin and calcitonin receptors — a separate system from the incretin compounds — and the most-cited research pairs it with a GLP-1 agonist on the basis that two satiety pathways may behave differently together than either does alone.

What has been studied

1
An amylin analogue
Cagrilintide is a long-acting analogue of amylin, a hormone released alongside insulin. It acts on amylin and calcitonin receptors — a different system from the incretin compounds.
2
Combination research
The most-cited work pairs it with a GLP-1 agonist, on the basis that two separate satiety pathways may behave differently together than either does alone.
3
Food intake models
Animal studies have measured food intake and body-weight change.

Research articles

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